The Birth of Epistructural Biology

By Weishi Meng Linus Pauling, the most gifted physical chemist that ever lived, once said that the realization of the relevance of the hydrogen bond, a relatively weak molecular force, gave birth to Structural Biology. He also said that there was more to it, a sort of meta-analysis of structural biology that was still missing. This he […]

Ariel Fernandez – Selected Publications

Selected publications of Ariel Fernández Ariel Fernandez Bibliography: 430 publications total. Ariel Fernández, Tobin R. Sosnick and Andrés Colubri: “Dynamics of hydrogen-bond desolvation in folding proteins”, Journal of Molecular Biology 321, 659-675 (2002). Ariel Fernández and Harold A. Scheraga: “Insufficiently dehydrated hydrogen bonds as determinants for protein interactions”, Proceedings of the National Academy of Sciences, […]

Inefficent selection as enabler in the evolution of human complexity

Rice University News Summary: A painstaking genomic and proteomic analysis has found a new evolutionary mechanism that accounts for some of the biological complexity of human beings. The scientists who found the mechanism say it helps humans cope with the consequences of inefficient natural selection. It fosters complexity by enabling human proteins to become more […]

Ariel Fernandez May Have Created a WaterMap Precursor in 2007

Contributed by Weishi L. Meng, reproduced from Science Transparency.    Drug designers often implement molecular therapies to block malfunctioning proteins that are causing disease. They do so by creating small molecules that bind to the intended protein target when suitably delivered. The procedure has its risks as unintended targets (off-target proteins) may also be hit or […]

Physics at the Biomolecular Interface: Review on Ariel Fernandez’s Book by Weishi Meng

Book Review by Weishi Meng (Reproduced with permission) “Physics at the Biomolecular Interface” is the latest book by Ariel Fernandez (阿列尔·费尔南德斯), the physical chemist and mathematician who developed the center manifold thermodynamics, unraveling the physical basis for the onset of life, and discovered the dehydron (脱水元), an idea that laid the foundation for the new field of epistructural biology. The hardcover is […]