Protein folding from first principles is passé. Rational drug design is passé.
We hear this too often and it surely sounds like sour grapes. Who would not want to solve the protein folding problem from first physical principles or rationally design drugs to hedge the enormous risks of the pharmaceutical industry? Why not admitting that we don’t really understand the science involved? Are these truly dauntingly complex problems or are we missing something fundamental in our physical understanding? Probably both, but this blog will hopefully address the latter problem.