PROTEIN FOLDING PROBLEM: IT’S THE MATRIX!

Solving the protein folding problem from physical principles is surely a daunting task and perhaps the main open challenge of the post-genomic era. It entails identifying the folding pathways that enable the protein to find its native structure and predict the latter solely from the amino acid sequence of the protein. Progress in this area has been hampered by unproductive borderline-theological discussions on the modeling […]

Book Critique: “Transformative Concepts for Drug Design: Target Wrapping”

The pharmaceutical world has been in a state of disarray for quite a while. With most low-hanging fruits already picked, drug discovery seems riskier and more uncertain than ever. Projects often get terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects […]