Physics at the Biomolecular Interface: Review on Ariel Fernandez’s Book by Weishi Meng

Book Review by Weishi Meng (Reproduced with permission) “Physics at the Biomolecular Interface” is the latest book by Ariel Fernandez (阿列尔·费尔南德斯), the physical chemist and mathematician who developed the center manifold thermodynamics, unraveling the physical basis for the onset of life, and discovered the dehydron (脱水元), an idea that laid the foundation for the new field of epistructural biology. The hardcover is […]

New treatment for heart failure: US Patent 9,051,387 by Richard Moss and Ariel Fernandez

The recently awarded US patent number 9051387 describes the first therapeutic disruption of a protein-protein association using a rationally designed man-made ligand, a challenge considered the holy grail in drug discovery. This invention by Richard Moss and Ariel Fernandez provides basically a treatment of heart failure. At the molecular level, the effect of the drug is […]

“Biomolecular Interfaces: Interactions, Functions and Drug Design”, the Latest Book by Ariel Fernandez

A new book by Ariel Fernandez has made its appearance on April 21, 2015. It is entitled “Biomolecular Interfaces: Interactions, Functions and Drug Design“. The publication particulars are: Hardcover: 372 pages Publisher: Springer; 2015 edition (April 21, 2015) Language: English ISBN-10: 3319168495 ISBN-13: 978-3319168494 Author: Ariel Fernandez Author Companies: Ariel Fernandez Consultancy; AF Innovation Author […]

Ariel Fernandez at the Center of a Biotechnological Transformation (Reproduced from Science Transparency)

Interview reproduced from Science Transparency. Ariel Fernandez (also styled as Ariel Fernandez Stigliano) is a physical chemist and mathematician and the former Karl F. Hasselmann Endowed Chair Professor of Bioengineering at Rice University. He got his Ph. D. in record time from Yale University under the guidance of Oktay Sinanoglu (who recently passed away according to Yale News). Completed in less than two […]


Dehydrons are disruptive structural defects in proteins in the form of solvent-exposed backbone hydrogen bonds. Dehydrons create interfacial tension and promote their own dehydration, hence they play a central role as determinants of protein associations. Recently, Ariel Fernández has shown that dehydrons are also vital components of the enzymatic apparatus [Ariel Fernandez: COMMUNICATION: Chemical functionality […]


Solving the protein folding problem from physical principles is surely a daunting task and perhaps the main open challenge of the post-genomic era. It entails identifying the folding pathways that enable the protein to find its native structure and predict the latter solely from the amino acid sequence of the protein. Progress in this area has been hampered by unproductive borderline-theological discussions on the modeling […]


MONUMENTAL as it surely is, Darwin’s opus does not contain a theory of evolution, at least in the scientific sense. It does not enable us to make verifiable predictions, the hallmark of validation for scientific theory. Many a-priori evolutionary outcomes could in principle result from within a scenario where selection pressure becomes operative. Darwin only explains the […]