Ariel Fernandez at the Center of a Biotechnological Transformation (Reproduced from Science Transparency)

Interview reproduced from Science Transparency. Ariel Fernandez (also styled as Ariel Fernandez Stigliano) is a physical chemist and mathematician and the former Karl F. Hasselmann Endowed Chair Professor of Bioengineering at Rice University. He got his Ph. D. in record time from Yale University under the guidance of Oktay Sinanoglu (who recently passed away according to Yale News). Completed in less than two […]

DEHYDRON: A PLAYER IN ENZYME CATALYSIS

Dehydrons are disruptive structural defects in proteins in the form of solvent-exposed backbone hydrogen bonds. Dehydrons create interfacial tension and promote their own dehydration, hence they play a central role as determinants of protein associations. Recently, Ariel Fernández has shown that dehydrons are also vital components of the enzymatic apparatus [Ariel Fernandez: COMMUNICATION: Chemical functionality […]

PROTEIN FOLDING PROBLEM: IT’S THE MATRIX!

Solving the protein folding problem from physical principles is surely a daunting task and perhaps the main open challenge of the post-genomic era. It entails identifying the folding pathways that enable the protein to find its native structure and predict the latter solely from the amino acid sequence of the protein. Progress in this area has been hampered by unproductive borderline-theological discussions on the modeling […]